Wadala has a large number of old temples, university campuses and is also home to the world's largest IMAX dome theater. It is also home to the Vidyalankar Educational Campus, whose building design has won an international award viz. Designshare's Honour award.
The BEST Transport Museum is also located at Wadala’s Anik Bus depot. It features amateur mini models of BEST buses and the ancient trams.

Wadala is also known for Churches, Temples and Dargas. Near the station is the 400 year oldVitthal Temple built by Sant Tukaram who brought the idol from Pandharpur— home of the original temple of Lord Vithal.

The temple is known as Prati Pandharpur (Pandharpur temple’s replica). One of the many one day festivals in Mumbai has been held in this temple to devote Lord Vitthal on Ashadhi Ekadashi (According to Hindu Calendar) in June/July.

Near this temple is the 15th-century Lord Ram temple and the Hanuman temple on the opposite side of the road. The Ram Temple also houses a marriage hall. On David S. Baretto road is located a Krishna Temple which also houses an orphanage.
Wadala also has a Balaji Temple, that celebrates the Jatrafestival each year in the month of January. Apart from these, there is also a Shiv Temple, a Devi Mandir and a small Gurudwara near the station.

The St. Joseph Church (Our lady of Dolours Church) is situated on the D.S Barretto Road, between Five Gardens and Wadala station. This also houses the St.Joseph's High School. Opposite this is the Don Bosco Shelter which is a centre for the rehabilitation and education of underprivileged children.
The Barkat Ali Dargah is located on a hill where the bridge connecting Wadala East to Wadala West ends. It is another of Wadala's landmarks.

The St. Dominic Savio Church is located in Wadala East. This church, built in 1981, was the first churches in Mumbai to be situated on the first floor.
Wadala (East) houses two cemeteries - the Bahá'í Cemetery and the Chinese Cemetery.
These cemeteries were laid out in Wadala a long time ago, for the same reason that the Ackworth Leprosy Home was built at Wadala viz. Wadala was considered a distant suburb of the city.